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Literature summary for 5.4.2.8 extracted from

  • Pirard, M.; Collet, J.F.; Matthijs, G.; van Schaftingen, E.
    Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells (1997), FEBS Lett., 411, 251-254.
    View publication on PubMed
Search for more literature for 5.4.2.8

Activating Compound

Activating Compound Comment Organism Structure
alpha-D-glucose 1,6-diphosphate or alpha-D-mannose 1,6-diphosphate required Homo sapiens
alpha-D-glucose 1,6-diphosphate or alpha-D-mannose 1,6-diphosphate required Rattus norvegicus
alpha-D-Mannose 1,6-diphosphate or alpha-D-glucose 1,6-diphosphate required Homo sapiens
alpha-D-Mannose 1,6-diphosphate or alpha-D-glucose 1,6-diphosphate required Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 mannose 1-phosphate
-
 Rattus norvegicus
0.0032
-
 mannose 1-phosphate recombinant enzyme PMM1 Homo sapiens
0.006
-
 alpha-D-glucose 1-phosphate recombinant enzyme PMM1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 2 * 30000, SDS-PAGE Homo sapiens
30000
-
 2 * 30000, SDS-PAGE Rattus norvegicus
60000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human liver enzyme and recombinant PMM1 from individuals with carbohydrate-deficient glycoprotein syndrome type I
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1-phosphate
-
 Homo sapiens D-glucose 6-phosphate
-
 ?
D-Mannose 1-phosphate
-
 Homo sapiens D-Mannose 6-phosphate
-
 ?
D-Mannose 1-phosphate
-
 Rattus norvegicus D-Mannose 6-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 30000, SDS-PAGE Homo sapiens
dimer 2 * 30000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Homo sapiens
6.5
-
-
 Rattus norvegicus