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Literature summary for 5.4.2.4 extracted from

  • Bertrand, R.
    Nitric oxide-mediated suppression of 2,3-bisphosphoglycerate synthesis: therapeutic relevance for environmental hypoxia and sickle cell disease (2012), Med. Hypotheses, 79, 315-318.
    View publication on PubMed
Search for more literature for 5.4.2.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-phospho-D-glyceroyl phosphate Homo sapiens
-
 2,3-bisphospho-D-glycerate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glyceroyl phosphate
-
 Homo sapiens 2,3-bisphospho-D-glycerate
-
 ?

Synonyms

Synonyms Comment Organism
BPG synthase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism NO may suppress 2,3-bisphospho-D-glycerate production by (1) inhibiting glyceraldehyde-3-phosphate dehydrogenase, the most critical glycolytic enzyme for the bioavailability of 1,3-bisphosphoglycerate, and to a lesser extent by (2) associated pH changes in the deoxy-hemoglobin-catalyzed depletion of nitrite, a metabolic reservoir of NO Homo sapiens
physiological function the enzyme is responsible for biosynthesis of 2,3-bisphospho-D-glycerate, which is an enhancer of oxygen off-loading from hemoglobin. It is very sensitive to changes in glycolytic rates because its synthesis by BPG synthase is dependent on the availability of the glycolytic intermediate 1,3-bisphosphoglycerate, metabolic enzyme regulation, overview Homo sapiens