Literature summary for 5.4.2.2 extracted from

Zhang, Y.; Li, T.; Zhang, J.; Li, Z.; Zhang, Y.; Wang, Z.; Feng, H.; Wang, Y.; Chen, C.; Zhang, H.
The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB/c mice (2016), World J. Microbiol. Biotechnol., 32, 58 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
alpha-D-Glucose 1,6-bisphosphate	dependent on	Brucella melitensis

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Brucella melitensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha-D-glucose 1-phosphate	Brucella melitensis	-	D-glucose 6-phosphate	-	?
alpha-D-glucose 1-phosphate	Brucella melitensis M5-90	-	D-glucose 6-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Brucella melitensis	-	-	-
Brucella melitensis M5-90	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Brucella melitensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-D-glucose 1-phosphate	-	Brucella melitensis	D-glucose 6-phosphate	-	?
alpha-D-glucose 1-phosphate	-	Brucella melitensis M5-90	D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PGM	-	Brucella melitensis

General Information

General Information	Comment	Organism
malfunction	an enzyme-deficient mutant shows significantly reduced survival in embryonic trophoblast cells and in mice, and induces high protective immunity in BALB/c mice. Moreover, the mutant elicits an anti-Brucella-specific immunoglobulin G response and induces the secretion of gamma interferon and interleukin-2	Brucella melitensis

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Release 2023.1 (January 2023)