Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-D-Glucose 1,6-bisphosphate | dependent on | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, mutant enzyme D263Y crystals grow in solutions including lithium or ammonium sulfate (1.4-1.55 M) with 0.1 M buffer of either MES, pH 6.0, or Tris HCl, pH 7.5. Crystals of mutant enzyme D263G grow from 1.6 M ammonium sulfate, 0.1 M NaCl, and 0.1 M HEPES, pH 7.5 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D263G | the mutation is associated with phosphoglucomutase 1 deficiency | Homo sapiens |
D263Y | the mutation is associated with phosphoglucomutase 1 deficiency | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-glucose 1-phosphate | Homo sapiens | - |
D-glucose 6-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36871 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-glucose 1-phosphate | - |
Homo sapiens | D-glucose 6-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PGM1 | - |
Homo sapiens |
phosphoglucomutase 1 | - |
Homo sapiens |