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Literature summary for 5.4.2.11 extracted from

  • Wang, P.; Jiang, L.; Cao, Y.; Ye, D.; Zhou, L.
    The design and synthesis of n-xanthone benzenesulfonamides as novel phosphoglycerate mutase 1 (PGAM1) inhibitors (2018), Molecules, 23, E1396 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.11

Inhibitors

Inhibitors Comment Organism Structure
2,6-dichloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
3-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
-
 Homo sapiens
4-(tert-butyl)-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
4-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
4-cyclohexyl-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
6-([1,1'-biphenyl]-4-sulfonamido)-8-hydroxy-9-oxo-9H-xanthen-2-yl acetate
-
 Homo sapiens
epigallocatechin gallate
-
 Homo sapiens
gemcitabine
-
 Homo sapiens
MJE3
-
 Homo sapiens
N-(1,7-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-3,5-difluorobenzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-fluorobenzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-5-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-5-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-7-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-7-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-7-nitro-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(7-chloro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
N-(7-fluoro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
 Homo sapiens
PGMI-004A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phospho-D-glycerate Homo sapiens
-
 3-phospho-D-glycerate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P18669
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
 Homo sapiens 3-phospho-D-glycerate
-
 ?

Synonyms

Synonyms Comment Organism
PGAM1
-
 Homo sapiens
phosphoglycerate mutase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000193
-
 at pH 8.0 and 25°C Homo sapiens gemcitabine
0.00049
-
 at pH 8.0 and 25°C Homo sapiens epigallocatechin gallate
0.0021
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-nitro-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0027
-
 at pH 8.0 and 25°C Homo sapiens 6-([1,1'-biphenyl]-4-sulfonamido)-8-hydroxy-9-oxo-9H-xanthen-2-yl acetate
0.0035
-
 at pH 8.0 and 25°C Homo sapiens N-(7-chloro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0046
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0055
-
 at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0059
-
 at pH 8.0 and 25°C Homo sapiens 4-cyclohexyl-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
0.006
-
 at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
0.0064
-
 at pH 8.0 and 25°C Homo sapiens 3-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
0.0064
-
 at pH 8.0 and 25°C Homo sapiens N-(1,7-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0065
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-5-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.008
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0084
-
 at pH 8.0 and 25°C Homo sapiens 4-(tert-butyl)-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
0.0086
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-5-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0101
-
 at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
0.0102
-
 at pH 8.0 and 25°C Homo sapiens 2,6-dichloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
0.0131
-
 at pH 8.0 and 25°C Homo sapiens PGMI-004A
0.0132
-
 at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-3,5-difluorobenzenesulfonamide
0.0137
-
 at pH 8.0 and 25°C Homo sapiens N-(7-fluoro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.0143
-
 at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
0.02
-
 at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
0.02
-
 IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
0.02
-
 IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
0.02
-
 IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
0.02
-
 IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-fluorobenzenesulfonamide
0.02
-
 IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
0.033
-
 at pH 8.0 and 25°C Homo sapiens MJE3