Literature summary for 5.4.2.11 extracted from

Mikawa, T.; Maruyama, T.; Okamoto, K.; Nakagama, H.; Lleonart, M.E.; Tsusaka, T.; Hori, K.; Murakami, I.; Izumi, T.; Takaori-Kondo, A.; Yokode, M.; Peters, G.; Beach, D.; Kondoh, H.
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2 (2014), J. Cell Biol., 204, 729-745 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-phospho-D-glycerate	Homo sapiens	-	3-phospho-D-glycerate	-	?
2-phospho-D-glycerate	Mus musculus	-	3-phospho-D-glycerate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15259	-	-
Mus musculus	O70250	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation	Homo sapiens
phosphoprotein	Pak1-mediated phosphorylation of phosphoglycerate mutase predisposes the enzyme to ubiquitin-mediated degradation	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
IMR-90 cell	-	Homo sapiens	-
MEF cell	-	Mus musculus	-
RKO cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-
TIG3 cell	-	Homo sapiens	-
WI-38 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-phospho-D-glycerate	-	Homo sapiens	3-phospho-D-glycerate	-	?
2-phospho-D-glycerate	-	Mus musculus	3-phospho-D-glycerate	-	?
additional information	Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro	Homo sapiens	?	-	?
additional information	Mdm2 is a direct binding partner and ubiquitin ligase for the enzyme in cultured cells and in vitro	Mus musculus	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 30000, SDS-PAGE	Homo sapiens
?	x * 30000, SDS-PAGE	Mus musculus

Synonyms

Synonyms	Comment	Organism
alpha-PGAM	-	Homo sapiens
alpha-PGAM	-	Mus musculus
PGAM2	-	Homo sapiens
PGAM2	-	Mus musculus

Expression

Organism	Comment	Expression
Homo sapiens	stress-induced down-regulation of the enzyme protein is observed in human primary fibroblasts but not in cancer cell lines	down

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Release 2023.1 (January 2023)