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Literature summary for 5.3.99.5 extracted from
- Inhibition of thromboxane A synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse leydig cells (2008), Endocrinology, 149, 851-857.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | treatment with enzyme-specific RNAi results in increased levels of steroidogenic acute regulatory protein StAR and steroidogenesis. Inhibition of enzyme activity reduces the levels of StaR transcriptional repressor DAX-1 | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| furegrelate | inhibition of thromboxane-A synthase, induces a concentration-dependent increase in cAMP-induced steroidogenic acute regulatory protein StAR concomitantly with a significant increase in steroid hormone production | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MA-10 cell | mouse leydig cells | Mus musculus | - |
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Release 2023.1 (January 2023)
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