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Literature summary for 5.3.99.5 extracted from

  • Sun, F.F.
    Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane synthetase (1977), Biochem. Biophys. Res. Commun., 74, 1432-1440.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
9,11(Epoxymethano) prostanoic acid
-
Homo sapiens
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid weak Homo sapiens
additional information the enzyme is not affected by nonsteroidal antiinflammatory agents Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid thromboxane A2 is an intermediate ?

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5 very little pH-dependence between pH 5-8.5, above pH 9.0 the reaction is significantly depressed Homo sapiens