Any feedback?
Literature summary for 5.3.99.5 extracted from
- Immunoaffinity purification and characterization of thromboxane synthase from porcine lung (1986), J. Biol. Chem., 261, 11592-11599.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (E)-3-[4-(1-Imidazolylmethyl)phenyl]-2-propenoate | reversible | Sus scrofa |  |
| 15-hydroperoxyeicosatetraenoic acid | - |
Sus scrofa | |
| 15-Hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid | reversible | Sus scrofa | |
| 15-Hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid | irreversible inactivation during catalysis, protection by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoate and 15-hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid | Sus scrofa | |
| Cu2+ | 1 mM, complete inhibition | Sus scrofa | |
| Zn2+ | 1 mM, 50% inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
15-hydroxy-9alpha,11alpha-peroxiprosta-5,13-dienoic acid | - |
Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| immunoaffinity purification | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.231 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15-hydroxy-9alpha,11alpha-peroxiprosta-5,13-dienoic acid | - |
Sus scrofa | ? | - |
? | |
| Prostaglandin H2 | i.e. PGH2 | Sus scrofa | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | the ratio of 12-hydroxy-5,8,10-heptadecatrienoic acid to thromboxane B2 varries from 1.6 to 2.1 depending on the reaction conditions | ? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | hemoprotein | Sus scrofa | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
Zn2+ | - |
Sus scrofa | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
