Literature summary for 5.3.99.5 extracted from

Hecker, M.; Haurand, M.; Ullrich, V.; Diczfalusy, U.; Hammarstr�m, S.
Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay (1987), Arch. Biochem. Biophys., 254, 124-135.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.022	-	prostaglandin H2	-	Homo sapiens
0.023	-	prostaglandin G2	prostaglandin H3	Homo sapiens
0.024	-	Prostaglandin H1	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 prostaglandin G2 + H2O	i.e. PGG2	Homo sapiens	15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid	-	?
2 prostaglandin H3 + H2O	-	Homo sapiens	thromboxane B3 + 12(L)-hydroxy-5,8,10,14-heptadecatetraenoic acid + malondialdehyde	the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1. Thromboxane A2 is fully transformed to thromboxane B2	?
prostaglandin H1	-	Homo sapiens	12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1	-	?
Prostaglandin H2	i.e. PGH2	Homo sapiens	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2	?
Prostaglandin H2	i.e. PGH2	Homo sapiens	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	+ malondialdehyde	?
Prostaglandin H2	i.e. PGH2	Homo sapiens	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1	?

Temperature Range [°C]

Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
20	37	activity at 37°C is not significantly higher than at 20°C	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
20.4	-	prostaglandin H3	-	Homo sapiens
26.7	-	prostaglandin H2	-	Homo sapiens
28.2	-	prostaglandin G2	-	Homo sapiens
59.4	-	prostaglandin H3	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	broad	Homo sapiens

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Release 2023.1 (January 2023)