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Literature summary for 5.3.99.4 extracted from

  • Ruan, K.H.; Deng, H.; So, S.P.
    Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin (2006), Biochemistry, 45, 14003-14011.
    View publication on PubMed

Application

Application Comment Organism
medicine upregulation of prostaglandin I2 synthesis by expression of a fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase shows strong activity in inhibiting platelet aggregation induced by arachidonic acid in vitro and may be used for therapeutic inventions for strokes and heart attacks Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, separated by a transmembrane domain of 10 or 22 residues Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, separated by a transmembrane domain of 10 or 22 residues. Expressed protein is able to convert arachidonic acid to prostaglandin G2, prostaglandin H2 and prostaglandin I2. Fusion protein may directly synthesize prostaglandin I2 from arachidonic acid with Km value of 0.0032 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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recombinant protein
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, is able to convert arachidonic acid to prostaglandin G2, prostaglandin H2 and prostaglandin I2. Fusion protein may directly synthesize prostaglandin I2 from arachidonic acid with Km value of 0.0032 mM Homo sapiens ?
-
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