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Literature summary for 5.3.99.4 extracted from

  • Tanabe, T.; Ullrich, V.
    Prostacyclin and thromboxane synthases (1995), J. Lipid Mediat. Cell Signal., 12, 243-255.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia ?
-
?
Prostaglandin H2 Sus scrofa formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Homo sapiens
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
-
aorta
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Homo sapiens Prostaglandin I2 prostaglandin I2 ?
Prostaglandin H2
-
Sus scrofa Prostaglandin I2 prostaglandin I2 ?
Prostaglandin H2 formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia Homo sapiens ?
-
?
Prostaglandin H2 formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
?
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Homo sapiens
cytochrome P450 cytochrome-P450 enzyme Sus scrofa