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Literature summary for 5.3.99.4 extracted from
- Prostacyclin- und Thromboxan-Synthase, neue Aspekte der Katalyse durch Hämthiolat-Enzyme (1994), Angew. Chem., 106, 1987-1996.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1R,2S)-2-phenylcyclopropanamine | - |
Bos taurus |  |
| (1R,2S)-2-phenylcyclopropanamine | - |
Sus scrofa | |
| 6-(1-Piperidyl)-2,4-diaminopyrimidine | weak | Bos taurus | |
| 6-(1-Piperidyl)-2,4-diaminopyrimidine | weak | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49200 | - |
x * 49200, SDS-PAGE | Sus scrofa |
| 52000 | - |
x * 52000, SDS-PAGE | Bos taurus |
| 56628 | - |
x * 56628, calculation from nucleotide sequence | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate | mechanism | Sus scrofa | |
| (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate | mechanism | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15-oxo-Prostaglandin H2 | - |
Sus scrofa | 15-oxo-Prostaglandin I2 + ? | - |
? | |
| 15-oxo-Prostaglandin H2 | - |
Bos taurus | 15-oxo-Prostaglandin I2 + ? | - |
? | |
| 8-iso-Prostaglandin H2 | - |
Sus scrofa | ? | - |
? | |
| 8-iso-Prostaglandin H2 | - |
Bos taurus | ? | - |
? | |
| prostaglandin G2 | - |
Sus scrofa | prostaglandin I2 + 15-hydroperoxyprostacyclin | - |
? | |
| prostaglandin H1 | - |
Bos taurus | 12-hydroxyheptadecadienoic acid + malondialdehyde | - |
? | |
| Prostaglandin H2 | - |
Sus scrofa | Prostaglandin I2 | prostaglandin I2 | ? | |
| Prostaglandin H2 | - |
Bos taurus | Prostaglandin I2 | prostaglandin I2 | ? | |
| Prostaglandin H3 | - |
Sus scrofa | Prostaglandin I3 | - |
? | |
| Prostaglandin H3 | - |
Bos taurus | Prostaglandin I3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52000, SDS-PAGE | Bos taurus |
| ? | x * 49200, SDS-PAGE | Sus scrofa |
| ? | x * 56628, calculation from nucleotide sequence | Bos taurus |
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