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Literature summary for 5.3.99.4 extracted from

  • Haurand, M.; Ullrich, V.
    Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis (1992), Front. Biotransform., 6, 183-199.
No PubMed abstract available
Search for more literature for 5.3.99.4

Inhibitors

Inhibitors Comment Organism Structure
2,4-Diamino-6-piperidinopyrimidine-3-oxide
-
 Sus scrofa
tranylcypromine
-
 Bos taurus
tranylcypromine
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-
microsome
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Sus scrofa
a
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Sus scrofa
-
aorta
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-trans-Prostaglandin H2
-
 Sus scrofa ?
-
 ?
prostaglandin G2
-
 Sus scrofa prostaglandin I2 + 15-hydroperoxyprostacyclin
-
 ?
Prostaglandin H2
-
 Sus scrofa Prostaglandin I2
-
 ?
Prostaglandin H2
-
 Bos taurus Prostaglandin I2
-
 ?
Prostaglandin H3
-
 Sus scrofa Prostaglandin I3
-
 ?
Prostaglandin H3
-
 Bos taurus Prostaglandin I3
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Bos taurus
cytochrome P450 cytochrome-P450 enzyme Sus scrofa
heme
-
 Bos taurus
heme contains 1 heme per 49000 MW polypeptide chain Sus scrofa