Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.99.3 extracted from

  • Werz, O.; Seegers, J.; Schaible, A.; Weinigel, C.; Barz, D.; Koeberle, A.; Allegrone, G.; Pollastro, F.; Zampieri, L.; Grassi, G.; Appendino, G.
    Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase (2014), PharmaNutrition, 2, 53-60 .
No PubMed abstract available
Search for more literature for 5.3.99.3

Inhibitors

Inhibitors Comment Organism Structure
cannflavin A
-
 Homo sapiens
cannflavin B
-
 Homo sapiens
MK-886
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
 Prostaglandin E2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Homo sapiens Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E2 synthase-1
-
 Homo sapiens
mPGES-1
-
 Homo sapiens
PGE2 synthase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0018
-
 at pH 7.4 and 4°C Homo sapiens cannflavin A
0.0037
-
 at pH 7.4 and 4°C Homo sapiens cannflavin B