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Literature summary for 5.3.99.3 extracted from
- Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods (2014), Comp. Biochem. Physiol. B, 174, 45-52 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | the enzyme activity is increased in the presence of reduced glutathione | Gammarus sp. KV-2010a |  |
| GSH | the enzyme activity is increased in the presence of reduced glutathione | Caprella sp. KV-2010a | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3)RP cells | Gammarus sp. KV-2010a |
| expressed in Escherichia coli BL21(DE3)RP cells | Caprella sp. KV-2010a |
General Stability
| General Stability | Organism |
|---|---|
| the enzyme stability is increased in the presence of reduced glutathione | Gammarus sp. KV-2010a |
| the enzyme stability is increased in the presence of reduced glutathione | Caprella sp. KV-2010a |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxymercuribenzoate | - |
Caprella sp. KV-2010a | |
| 4-hydroxymercuribenzoate | - |
Gammarus sp. KV-2010a | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Gammarus sp. KV-2010a | 16020 | - |
| membrane | - |
Caprella sp. KV-2010a | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | Gammarus sp. KV-2010a | - |
Prostaglandin E2 | - |
? | |
| Prostaglandin H2 | Caprella sp. KV-2010a | - |
Prostaglandin E2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caprella sp. KV-2010a | S4VIU3 | - |
- |
| Gammarus sp. KV-2010a | S4VLK7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography, and Superdex 200 gel filtration | Gammarus sp. KV-2010a |
| Ni-NTA column chromatography, and Superdex 200 gel filtration | Caprella sp. KV-2010a |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | - |
Gammarus sp. KV-2010a | Prostaglandin E2 | - |
? | |
| Prostaglandin H2 | - |
Caprella sp. KV-2010a | Prostaglandin E2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 39000, N-terminally truncated His6-tagged enzyme, SDS-PAGE | Gammarus sp. KV-2010a |
| ? | x * 39000, N-terminally truncated His6-tagged enzyme, SDS-PAGE | Caprella sp. KV-2010a |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGE synthase | - |
Gammarus sp. KV-2010a |
| PGE synthase | - |
Caprella sp. KV-2010a |
| PGES-2 | - |
Gammarus sp. KV-2010a |
| PGES-2 | - |
Caprella sp. KV-2010a |
| prostaglandin E synthase-2 | - |
Gammarus sp. KV-2010a |
| prostaglandin E synthase-2 | - |
Caprella sp. KV-2010a |
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Release 2023.1 (January 2023)
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