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Literature summary for 5.3.99.3 extracted from

  • Barbieri, S.S.; Amadio, P.; Gianellini, S.; Zacchi, E.; Weksler, B.B.; Tremoli, E.
    Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase (2011), FASEB J., 25, 3731-3740.
    View publication on PubMed
Search for more literature for 5.3.99.3

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac endothelial cell
-
 Mus musculus
-
cardiac endothelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Mus musculus
mPGES-1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus inhibition of NADPH-oxidase negatively modulates mPGES-1 expression induced by tobacco smoke/interleukin-1beta. The activation of mPGES-1 is negatively regulated by prostaglandin I2 down
Mus musculus tobacco smoke (EC50 about 5 puffs/l) interacting with IL-1beta (0.002 mg/l) upregulates PGE2 production and mPGES-1 expression, reaching a plateau at 4-6 h up