Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-2-[4-[3-(2,3-dimethylphenoxy)propoxy]benzylidene]hexanoic acid | 28.3% residual activity at 0.01 mM | Homo sapiens | |
(2R)-2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
(2S)-2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)acetic acid | 75.4% residual activity at 0.01 mM | Homo sapiens | |
2(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(2-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | 88.3% residual activity at 0.01 mM | Homo sapiens | |
2-([4-[3-(2-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(3-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | 59.1% residual activity at 0.01 mM | Homo sapiens | |
2-([4-[3-(3-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | 58% residual activity at 0.01 mM | Homo sapiens | |
2-([4-[3-(4-chloro-2-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(4-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-([4-[3-(quinolin-6-yloxy)propoxy]phenyl]sulfanyl)hexanoic acid | - |
Homo sapiens | |
2-[(4-[3-[2-(propan-2-yl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | - |
Homo sapiens | |
2-[(4-[3-[3-(propan-2-yl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | - |
Homo sapiens | |
2-[(4-[3-[3-(trifluoromethyl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | - |
Homo sapiens | |
2-[(4-[3-[4-chloro-3-(trifluoromethyl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | - |
Homo sapiens | |
2-[4-[3-(2,3-dimethylphenoxy)propoxy]benzyl]hexanoic acid | - |
Homo sapiens | |
2-[[4-(3-phenoxypropoxy)phenyl]sulfanyl]hexanoic acid | 81.9% residual activity at 0.01 mM | Homo sapiens | |
3-[4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]propanoic acid | 83.9% residual activity at 0.01 mM | Homo sapiens | |
ethyl 2-([4-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propoxy]phenyl]sulfanyl)hexanoate | - |
Homo sapiens | |
ethyl 2-([4-[3-(biphenyl-4-yloxy)propoxy]phenyl]sulfanyl)hexanoate | - |
Homo sapiens | |
ethyl 2-([4-[3-(quinolin-6-yloxy)propoxy]phenyl]sulfanyl)hexanoate | 83.9% residual activity at 0.01 mM | Homo sapiens | |
MK886 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0017 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[(4-[3-[4-chloro-3-(trifluoromethyl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | |
0.002 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[(4-[3-[3-(trifluoromethyl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | |
0.0022 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0022 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid | |
0.0024 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | MK886 | |
0.0027 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[(4-[3-[3-(propan-2-yl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | |
0.0029 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0041 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[(4-[3-[2-(propan-2-yl)phenoxy]propoxy]phenyl)sulfanyl]hexanoic acid | |
0.0042 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | (2R)-2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0046 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | (2S)-2-([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0071 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[4-[3-(2,3-dimethylphenoxy)propoxy]benzyl]hexanoic acid | |
0.0088 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(2-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0093 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(4-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.0094 | - |
in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(4-chloro-2-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | ([4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]sulfanyl)acetic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 3-[4-[3-(2,3-dimethylphenoxy)propoxy]phenyl]propanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | (2E)-2-[4-[3-(2,3-dimethylphenoxy)propoxy]benzylidene]hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-[[4-(3-phenoxypropoxy)phenyl]sulfanyl]hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(3-methylphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(2-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(3-methoxyphenoxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | 2-([4-[3-(quinolin-6-yloxy)propoxy]phenyl]sulfanyl)hexanoic acid | |
0.01 | - |
IC50 above 0.01 mM, in 0.1 M potassium phosphate buffer, pH 7.4, at 4°C | Homo sapiens | ethyl 2-([4-[3-(quinolin-6-yloxy)propoxy]phenyl]sulfanyl)hexanoate |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interleukin-1beta (1 ng/ml) induces mPGES-1 expression | up |