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Literature summary for 5.3.99.3 extracted from

  • Ae, T.; Ohno, T.; Hattori, Y.; Suzuki, T.; Hosono, K.; Minamino, T.; Sato, T.; Uematsu, S.; Akira, S.; Koizumi, W.; Majima, M.
    Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers (2010), Am. J. Physiol. Gastrointest. Liver Physiol., 299, G1139-G1146.
    View publication on PubMed
Search for more literature for 5.3.99.3

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
 Prostaglandin E2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
stomach
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Mus musculus
mPGES-1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of mPGES-1 in wild type mice is markedly upregulated in the gastric ulcer tissues compared with normal gastric tissues without ulcers up

General Information

General Information Comment Organism
malfunction the healing of acetic acid-induced gastric ulcers is significantly delayed in mPGES-1 knockout mice compared with wild type. This is accompanied with reduced angiogenesis in ulcer granulation tissues. The mRNA levels of proangiogenic growth factors, such as transforming growth factor-beta, basic fibroblast growth factor, and connective tissue growth factor are reduced in mPGES-1 knockout mice compared with wild type Mus musculus
physiological function mPGES-1 enhances the gastric ulcer-healing processes and the angiogenesis indispensable to gastric ulcer healing Mus musculus