Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MK-886 | glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher | Mus musculus | |
MK-886 | glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? | |
Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Mus musculus |
microsomal prostaglandin E synthase-1 | - |
Rattus norvegicus |
mPGES-1 | - |
Mus musculus |
mPGES-1 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0024 | - |
- |
Mus musculus | MK-886 | |
0.0024 | - |
- |
Rattus norvegicus | MK-886 |
Organism | Comment | Expression |
---|---|---|
Mus musculus | 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls | up |
Rattus norvegicus | 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls | up |
General Information | Comment | Organism |
---|---|---|
physiological function | microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury | Mus musculus |
physiological function | microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury | Rattus norvegicus |