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Literature summary for 5.3.99.3 extracted from

  • Megias, J.; Guillen, M.I.; Clerigues, V.; Rojo, A.I.; Cuadrado, A.; Castejon, M.A.; Gomar, F.; Alcaraz, M.J.
    Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes (2009), Biochem. Pharmacol., 77, 1806-1813.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
 Prostaglandin E2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte osteoarthritic chondrocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Homo sapiens Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Homo sapiens
mPGES-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.01 mM cobalt protoporphyrin IX down-regulates mPGES-1 protein down
Homo sapiens 100 units/ml interleukin-1beta induces the expression of COX-2 and mPGES-1 in osteoarthritic chondrocytes up