Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1beta | - |
Homo sapiens | |
LPS | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | mPGES-1 plays a role in atherosclerosis, stroke, inflammation, pain and fever | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
15-deoxy-DELTA12,14-prostaglandin J2 | - |
Homo sapiens | |
2-(2-chloro-6-fluorophenyl)-9-fluoro-3,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one | - |
Homo sapiens | |
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
2-[6-(2-cyclopropylethoxy)-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
2-[6-bromo-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
2-[6-chloro-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
2-[6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
3-(1-benzothiophen-2-yl)-2-bromo-5-hydroxycyclopent-2-en-1-one | - |
Homo sapiens | |
3-benzamidocarbazole | - |
Homo sapiens | |
3-[1-(4-chlorobenzyl)-5-(2-fluoro-5-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
3-[1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
3-[3-(benzylsulfanyl)-1-(4-chlorobenzyl)-5-[4-[(4-chloro-2-fluorophenyl)ethynyl]phenyl]-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
4-(4-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole | - |
Homo sapiens | |
5-(4-cyclohexylphenyl)-1-[4-(1-methylethoxy)benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
5-(4-tert-butylphenyl)-1-[4-(1-methylethoxy)benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
5-(4-tert-butylphenyl)-3-[4-(1-methylethoxy)phenyl]-1-[4-[(1-methylethyl)amino]benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
7-hydroxy-N,N'-bis(2,4,6-trimethylphenyl)naphthalene-1,3-disulfonamide | - |
Homo sapiens | |
acetaminophen | - |
Homo sapiens | |
arachidonic acid | - |
Homo sapiens | |
biarylimidazole | - |
Homo sapiens | |
cysteinyl leukotriene LTC4 | - |
Homo sapiens | |
eicosapentaenoic acid | - |
Homo sapiens | |
methyl 4-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]but-3-ynoate | - |
Homo sapiens | |
MK-886 | - |
Homo sapiens | |
N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-(trifluoromethyl)benzamide | - |
Homo sapiens | |
NS-398 | - |
Homo sapiens | |
resveratrol | - |
Homo sapiens | |
sulindac sulfide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | Homo sapiens | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
seminal vesicle | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000007 | - |
- |
Homo sapiens | 2-[6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
0.0000008 | - |
- |
Homo sapiens | biarylimidazole | |
0.0000009 | - |
- |
Homo sapiens | 2-[6-(2-cyclopropylethoxy)-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
0.0000009 | - |
- |
Homo sapiens | 2-[6-bromo-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
0.0000009 | - |
- |
Homo sapiens | 2-[6-chloro-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
0.000001 | - |
- |
Homo sapiens | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile | |
0.0000017 | - |
- |
Homo sapiens | methyl 4-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]but-3-ynoate | |
0.00006 | - |
- |
Homo sapiens | 3-[3-(benzylsulfanyl)-1-(4-chlorobenzyl)-5-[4-[(4-chloro-2-fluorophenyl)ethynyl]phenyl]-1H-indol-2-yl]-2,2-dimethylpropanoic acid | |
0.0003 | - |
- |
Homo sapiens | arachidonic acid | |
0.0003 | - |
- |
Homo sapiens | eicosapentaenoic acid | |
0.0003 | - |
- |
Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin J2 | |
0.00039 | - |
- |
Homo sapiens | 4-(4-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole | |
0.0011 | - |
- |
Homo sapiens | 7-hydroxy-N,N'-bis(2,4,6-trimethylphenyl)naphthalene-1,3-disulfonamide | |
0.0012 | - |
- |
Homo sapiens | cysteinyl leukotriene LTC4 | |
0.0013 | - |
- |
Homo sapiens | N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-(trifluoromethyl)benzamide | |
0.0018 | - |
- |
Homo sapiens | 3-(1-benzothiophen-2-yl)-2-bromo-5-hydroxycyclopent-2-en-1-one | |
0.002 | - |
- |
Homo sapiens | 3-benzamidocarbazole | |
0.0032 | - |
- |
Homo sapiens | MK-886 | |
0.02 | - |
- |
Homo sapiens | NS-398 | |
0.044 | - |
- |
Homo sapiens | acetaminophen | |
0.08 | - |
- |
Homo sapiens | sulindac sulfide |