Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin 1beta | stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms mPGES-1 and cPGES | - |
Homo sapiens | Q9H7Z7 | isoform mPGES-2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myometrium | isoform mPGES-1 localizes mostly in myometrial and vascular smooth muscle cells of pregnant women. Isoform cPGES is diffusely located throughout the myometrium. Expression of COX-2 and isoform mPGES-1 mRNA with term labour, whereas cPGES expression does not change. Interleukin 1beta stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression | Homo sapiens | - |
myometrium | isoform mPGES-2 protein is largely in stromal cells surrounding smooth vascular muscle. Expression of mPGES-2 mRNA increases with term labour and preterm labour | Homo sapiens | - |