Literature summary for 5.3.99.3 extracted from

Mosca, M.; Polentarutti, N.; Mangano, G.; Apicella, C.; Doni, A.; Mancini, F.; De Bortoli, M.; Coletta, I.; Polenzani, L.; Santoni, G.; Sironi, M.; Vecchi, A.; Mantovani, A.
Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils (2007), J. Leukocyte Biol., 82, 320-326.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform mPGES-1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
monocyte	peripheral blood monocyte, no basal expression of enzyme, but strong induction of expression by proinflammatory stimulation via LPS. In alternatively activated M2 monocytes-macrophages, interleukins IL-4, IL-13, and to a lesser extent, IL-10 or interferon IFN-gamma inhibit LPS-induced expression of enzyme. Induction of enzyme expression correlates with changes at the protein level and production of prostaglandin E2	Homo sapiens	-

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Release 2023.1 (January 2023)