Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Mus musculus | |
additional information | IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2 | Mus musculus | |
additional information | proinflammatory stimuli | Rattus norvegicus | |
thiol reagents | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | the enzyme represents a novel target for anti-inflammatory and anti-cancer drugs | Rattus norvegicus |
medicine | a considerable increase of mPGES-2 expression is observed in human colorectal cancer | Homo sapiens |
medicine | mPGES-1 is involved in various types of pathology including inflammation, pain hyperalgesia, fever, and cancer | Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | anti-inflammatory glucocorticoids | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
microsome | perinuclear | Rattus norvegicus | - |
- |
microsome | Golgi membrane-associated | Homo sapiens | - |
- |
additional information | cPGES is directly associated with and phosphorylated by casein kinase 2, cPGES, casein kinase 2 and Hsp90 form a stoichiometric complex of 1:1:1 immediately after cell activation, Hsp90 acts as an essential scaffold protein that brings cPGES and casein kinase 2 in proximity, thereby allowing their efficient functional interaction under physiological condition | Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? | |
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? | |
Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin E2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | crystal structure | Homo sapiens |
trimer | crystal structure | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
CPGES | - |
Mus musculus |
mPGES-1 | - |
Rattus norvegicus |
mPGES-2 | - |
Homo sapiens |
PGES | - |
Mus musculus |
PGES | - |
Homo sapiens |
PGES | - |
Rattus norvegicus |
Prostaglandin E synthase | - |
Mus musculus |
Prostaglandin E synthase | - |
Homo sapiens |
Prostaglandin E synthase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Rattus norvegicus |