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Literature summary for 5.3.99.2 extracted from

  • Virtue, S.; Masoodi, M.; Velagapudi, V.; Tan, C.Y.; Dale, M.; Suorti, T.; Slawik, M.; Blount, M.; Burling, K.; Campbell, M.; Eguchi, N.; Medina-Gomez, G.; Sethi, J.K.; Ore?i?, M.; Urade, Y.; Griffin, J.L.; Vidal-Puig, A.
    Lipocalin prostaglandin D synthase and PPARgamma2 coordinate to regulate carbohydrate and lipid metabolism in vivo (2012), PLoS ONE, 7, e39512.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.99.2

Protein Variants

Protein Variants Comment Organism
additional information generation of double knock out mice lacking lipocalin prostaglandin D synthase and PPARgamma2 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules ?
-
 ?
additional information Mus musculus C57BL/6 the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male
-
Mus musculus C57BL/6
-
 male
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
 Mus musculus
-
epididymis
-
 Mus musculus
-
white adipose tissue e.g. epididymal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules Mus musculus ?
-
 ?
additional information the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
L-PGDS
-
 Mus musculus
lipocalin prostaglandin D synthase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus mice lacking PPARgamma2 have elevated levels of lipocalin prostaglandin D synthase expression in brown adipose tissue and subcutaneous white adipose tissue up

General Information

General Information Comment Organism
malfunction double knockout mice, lacking lipocalin prostaglandin D synthase as well as PPARgamma2, have impaired carbohydrate and lipid metabolism with glucose tolerance compared to any other genotypes, their interscapular brown adipose tissue exhibits greater lipid content than that of wild-type mice, which is independent of PPARgamma2 dysfunction. In subcutaneous white adipose tissue, L-PGDS KO mice exhibit a 4fold increase in UCP1 expression and a reduction in adipogenic marker aP2 expression. Phenotypes, overview Mus musculus
physiological function requirement of the enzyme for maintenance of subcutaneous white adipose tissue function. The enzyme and peroxisome proliferator-activated receptor gamma2 coordinate to regulate carbohydrate and lipid metabolism Mus musculus