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Literature summary for 5.3.99.2 extracted from

  • Hokari, R.; Nagata, N.; Kurihara, C.; Watanabe, C.; Komoto, S.; Okada, Y.; Kawaguchi, A.; Nagao, S.; Hibi, T.; Nagata, K.; Urade, Y.; Miura, S.
    Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis (2009), J. Pathol., 219, 417-426.
    View publication on PubMed
Search for more literature for 5.3.99.2

Application

Application Comment Organism
medicine based on the observations it is speculated that PGD2 acts as one of the immuno-modulating molecules in gastric mucosa infected with Helicobacter pylori, PGD2 might be involved in the pathophysiology of other gastric diseases, such as gastric ulcers or erosion Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the coding region of human L-PGDS is sub-cloned into pCR-Script Amp SK+ vector Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
 Prostaglandin D2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
gastric mucosa
-
 Homo sapiens
-
glandular epithelium L-PGDS is constitutively expressed in the epithelium of the glandular base Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

Synonyms Comment Organism
H-PGDS
-
 Homo sapiens
haematopoietic prostaglandin D synthase
-
 Homo sapiens
L-PGDS
-
 Homo sapiens
lipocalin-type prostaglandin d synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens level of L-PGDS mRNA expression decreases as gastritis becomes more severe down
Homo sapiens L-PGDS, but not H-PGDS, is induced on fibroblasts close to infiltrating cells in the Helicobacter pylori-infected gastric mucosa up