Literature summary for 5.3.4.1 extracted from

Conant, C.G.; Stephens, R.S.
Chlamydia attachment to mammalian cells requires protein disulfide isomerase (2007), Cell. Microbiol., 9, 222-232.

Cloned(Commentary)

Cloned (Comment)	Organism
PDI cloning from CHO-K1 cells, expression as N-terminally HA-tagged enzyme in GP2-293 cells, complementation by expression of full-length PDI restores Chlamydia trachomatis binding and infectivity in the enzyme-deficient CHO-6 mutant cell line, as wellas to diphtheria toxin sensitivity, PDI might complement an endoplasmic reticulum transport function, or other indirect functions, resulting in the change of phenotype for chlamydial susceptibility, overview	Cricetulus griseus

Cloned (Comment)

Organism

PDI cloning from CHO-K1 cells, expression as N-terminally HA-tagged enzyme in GP2-293 cells, complementation by expression of full-length PDI restores Chlamydia trachomatis binding and infectivity in the enzyme-deficient CHO-6 mutant cell line, as wellas to diphtheria toxin sensitivity, PDI might complement an endoplasmic reticulum transport function, or other indirect functions, resulting in the change of phenotype for chlamydial susceptibility, overview

Cricetulus griseus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Cricetulus griseus	9986	-
plasma membrane	-	Cricetulus griseus	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Cricetulus griseus	the enzyme is involved in diphtheria toxin sensitivity and is required for toxin entry, Chlamydia trachomatis or Chlamydia psittaci, intracellular pathogens of humans, require the enzyme for attachment to mammalian CHO6 cells, host cell invasion is obligatory for survival, growth and pathogenesis, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO-6 cell	-	Cricetulus griseus	-
CHO-K1 cell	-	Cricetulus griseus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in diphtheria toxin sensitivity and is required for toxin entry, Chlamydia trachomatis or Chlamydia psittaci, intracellular pathogens of humans, require the enzyme for attachment to mammalian CHO6 cells, host cell invasion is obligatory for survival, growth and pathogenesis, overview	Cricetulus griseus	?	-	?

Synonyms

Synonyms	Comment	Organism
PDI	-	Cricetulus griseus
protein disulfide isomerase	-	Cricetulus griseus