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Literature summary for 5.3.3.5 extracted from

  • Berardi, F.; Abate, C.; Ferorelli, S.; de Robertis, A.F.; Leopoldo, M.; Colabufo, N.A.; Niso, M.; Perrone, R.
    Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as DELTA8-DELTA7 sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity (2008), J. Med. Chem., 51, 7523-7531.
    View publication on PubMed
Search for more literature for 5.3.3.5

Inhibitors

Inhibitors Comment Organism Structure
(+)-pentazocine
-
 Homo sapiens
(+/-)-ifenprodil
-
 Homo sapiens
1,3-di-2-tolylguanidine
-
 Homo sapiens
1-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-phenylpiperazine
-
 Homo sapiens
1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[4-(3-methoxyphenyl)cyclohexyl]-4-phenylpiperazine
-
 Homo sapiens
1-[cis-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[cis-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[cis-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[trans-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[trans-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
1-[trans-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
3-[4-(4-naphthalen-1-ylpiperazin-1-yl)cyclohexyl]phenyl hydroperoxide
-
 Homo sapiens
4-[1-(2,6-dimethylphenyl)-3-cyclohexen-4-yl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-[4-(2,6-dimethylyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
cis-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
-
 Homo sapiens
N-(2-phenylethyl)piperidine
-
 Homo sapiens
trans-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
trans-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
trans-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
trans-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
trans-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-cholesta-8,24-dien-3beta-ol
-
 Homo sapiens 5alpha-cholesta-7,24-dien-3beta-ol
-
 ?
dihydrozymosterol
-
 Homo sapiens lathosterol
-
 ?

Synonyms

Synonyms Comment Organism
3beta-hydroxysteroid DELTA8-DELTA7 isomerase
-
 Homo sapiens
Delta8-delta7 sterol isomerase
-
 Homo sapiens
EBP
-
 Homo sapiens
Emopamil binding protein
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000495
-
 cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.000005
-
 cis-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.000007
-
 trans-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.00000721
-
 trans-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.00000815
-
 1-[cis-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.00000904
-
 trans-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.0000135
-
 1-[trans-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000146
-
 N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
-
 Homo sapiens
0.0000162
-
 1-[trans-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000164
-
 (+/-)-ifenprodil
-
 Homo sapiens
0.0000167
-
 3-[4-(4-naphthalen-1-ylpiperazin-1-yl)cyclohexyl]phenyl hydroperoxide
-
 Homo sapiens
0.0000168
-
 trans-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.0000321
-
 1-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000328
-
 1-[cis-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000331
-
 cis-4-[4-(2,6-dimethylyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.0000454
-
 1-[cis-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000467
-
 4-[1-(2,6-dimethylphenyl)-3-cyclohexen-4-yl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.0000492
-
 cis-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.0000716
-
 1-[trans-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.0000851
-
 cis-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.000106
-
 trans-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.00014
-
 cis-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
0.00046
-
 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-phenylpiperazine
-
 Homo sapiens
0.000595
-
 N-(2-phenylethyl)piperidine
-
 Homo sapiens
0.00171
-
 1-[4-(3-methoxyphenyl)cyclohexyl]-4-phenylpiperazine
-
 Homo sapiens
0.00264
-
 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
0.00766
-
 1,3-di-2-tolylguanidine
-
 Homo sapiens
0.01
-
 (+)-pentazocine Ki above 0.01 mM Homo sapiens