Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3beta-[2-(diethylamino)ethoxy]androst-5-en-17-one | IC50: 0.0042 mM | Rattus norvegicus | |
trans-2-[4-(1,2-diphenylbuten-1-yl)phenoxy]-N,N-dimethylethylamine | IC50: 0.0112 mM | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26737 | - |
x * 26737, calculation from nucleotide sequence | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholest-7-en-3beta-ol | Rattus norvegicus | enzyme of the cholesterol biosynthetic pathway, mutations are associated with Conradi-Huenermann syndrome. The enzyme may be involved in liver function, since the mRNA is only detected in hepatocytes not in connective tissue or blood vessels. The expression of the SI gene is regulated transcriptionally in vitro and in vivo by widely known regulatory agents ranging from tamoxifen, an oestrogen receptor antagonist and SI-specific inhibitor, to cholesterol-lowering drugs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9JJ46 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholest-7-en-3beta-ol | enzyme of the cholesterol biosynthetic pathway, mutations are associated with Conradi-Huenermann syndrome. The enzyme may be involved in liver function, since the mRNA is only detected in hepatocytes not in connective tissue or blood vessels. The expression of the SI gene is regulated transcriptionally in vitro and in vivo by widely known regulatory agents ranging from tamoxifen, an oestrogen receptor antagonist and SI-specific inhibitor, to cholesterol-lowering drugs | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26737, calculation from nucleotide sequence | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
SI | - |
Rattus norvegicus |
sterol DELTA8 isomerase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0042 | - |
IC50: 0.0042 mM | Rattus norvegicus | 3beta-[2-(diethylamino)ethoxy]androst-5-en-17-one | |
0.0112 | - |
IC50: 0.0112 mM | Rattus norvegicus | trans-2-[4-(1,2-diphenylbuten-1-yl)phenoxy]-N,N-dimethylethylamine |