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Literature summary for 5.3.3.2 extracted from

  • Thibodeaux, C.J.; Mansoorabadi, S.O.; Kittleman, W.; Chang, W.C.; Liu, H.W.
    Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus (2008), Biochemistry, 47, 2547-2558.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase
-

Reaction

Reaction Comment Organism Reaction ID
Isopentenyl diphosphate = dimethylallyl diphosphate in the rate determining step, the C2-H bond of isopentenyl diphosphate is cleaved. General acid/base catalysis may be involved during turnover Staphylococcus aureus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isopentenyl diphosphate accumulation of a reduced neutral dihydroflavin intermediate upon incubation of the reduced enzyme with isopentenyl diphosphate or dimethylallyl diphosphate. The intermediate forms and decays at kinetically competent rates in the pre-steady-state Staphylococcus aureus dimethylallyl diphosphate
-
 r