Literature summary for 5.3.3.12 extracted from

Fingerle-Rowson, G.; Kaleswarapu, D.R.; Schlander, C.; Kabgani, N.; Brocks, T.; Reinart, N.; Busch, R.; Schuetz, A.; Lue, H.; Du, X.; Liu, A.; Xiong, H.; Chen, Y.; Nemajerova, A.; Hallek, M.; Bernhagen, J.; Leng, L.; Bucala, R.
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation (2009), Mol. Cell. Biol., 29, 1922-1932.

Cloned(Commentary)

Cloned (Comment)	Organism
gene mif	Mus musculus

Protein Variants	Comment	Organism
P1G	generation of knockout mice in which the endogenous mif gene is replaced by one encoding a tautomerase-null, Pro1-Gly1 MIF protein, i.e. P1G-MIF, which is P1G-MIF is catalytically completely inactive, but maintains significant, albeit reduced, binding to its cell surface receptor CD74 and to the intracellular binding protein JAB1/CSN5. Mutant mice show a phenotype in assays of growth control and tumor induction that is intermediate between those of the wild type mif+/+ and complete MIF deficiency mif-/-, overview. Reduced development of benzo[alpha]pyrene-induced skin tumors in mif-deficient mice	Mus musculus

Organism	UniProt	Comment	Textmining
Mus musculus	-	gene mif	-

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-
macrophage	-	Mus musculus	-

Synonyms	Comment	Organism
D-dopachrome tautomerase	-	Mus musculus
macrophage migration-inhibitory factor	-	Mus musculus
MIF	-	Mus musculus

General Information	Comment	Organism
physiological function	MIF is an upstream regulator of innate immunity and a potential molecular link between inflammation and cancer, functional role of the MIF tautomerase activity in vivo, overview. MIF's intrinsic tautomerase activity is dispensable for this cytokine's growth-regulatory properties and support a role for the N-terminal region in protein-protein interactions	Mus musculus