Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epostane | - |
Homo sapiens | |
trilostane | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0175 | - |
dehydroepiandrosterone | mutant R240Q, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.0279 | - |
dehydroepiandrosterone | wild-type, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.033 | - |
dehydroepiandrosterone | mutant Q105M, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.0623 | - |
dehydroepiandrosterone | mutant Q240R, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.0808 | - |
dehydroepiandrosterone | mutant Q105M, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.0884 | - |
dehydroepiandrosterone | wild-type, isoform 2, 27°C, pH 7.4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
bifunctional 3beta-hydroxysteroid dehydrogenase/isomerase, isoforms type 1 and 2 | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone | - |
Homo sapiens | 3beta-hydroxy-4-androsten-17-one | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1990 | - |
dehydroepiandrosterone | mutant Q240R, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
2064 | - |
dehydroepiandrosterone | mutant R240Q, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
2088 | - |
dehydroepiandrosterone | mutant Q105M, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
3012 | - |
dehydroepiandrosterone | wild-type, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
4002 | - |
dehydroepiandrosterone | mutant Q105M, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
4890 | - |
dehydroepiandrosterone | wild-type, isoform 2, 27°C, pH 7.4 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | isomerase activity of enzyme requires NADH, Km- and kcat-value of isoform 1 wild-type are 0.0046 mM and 45 per min, resp. Km- and kcat-value of isoform 2 wild-type are 0.0126 mM and 99.1 per min, resp | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
epostane | mutant Q240R, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.00007 | - |
epostane | wild-type, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.0001 | - |
trilostane | wild-type, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.00012 | - |
trilostane | mutant R240Q, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00013 | - |
trilostane | mutant Q240R, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.00021 | - |
epostane | mutant R240Q, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00098 | - |
epostane | wild-type, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00164 | - |
epostane | mutant Q105M, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00166 | - |
trilostane | wild-type, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00184 | - |
epostane | mutant Q105M, isoform 1, 27°C, pH 7.4 | Homo sapiens | |
0.00207 | - |
trilostane | mutant Q105M, isoform 2, 27°C, pH 7.4 | Homo sapiens | |
0.00208 | - |
trilostane | mutant Q105M, isoform 1, 27°C, pH 7.4 | Homo sapiens |