Literature summary for 5.3.3.1 extracted from

Penning, T.M.; Covey, D.F.; Talalay, P.
Irreversible inactivation of DELTA5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct (1981), J. Biol. Chem., 256, 6842-6850.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.048	-	5,10-Seco-19-norpregn-5-yne-3,10,20-trione	-	Comamonas testosteroni
0.068	-	5-Pregnene-3,20-dione	-	Comamonas testosteroni
0.38	-	5-androstene-3,17-dione	-	Comamonas testosteroni
0.413	-	5,10-secoestr-5-yne-3,10,20,trione	-	Comamonas testosteroni

Organism

Organism	UniProt	Comment	Textmining
Comamonas testosteroni	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-Seco-19-norpregn-5-yne-3,10,20-trione	i.e. pregnyne	Comamonas testosteroni	?	-	?
5,10-Secoestr-5-yne-3,10,17-trione	i.e. estryne	Comamonas testosteroni	?	-	?
5-Androstene-3,17-dione	-	Comamonas testosteroni	4-Androstene-3,17-dione	-	?
5-Pregnene-3,20-dione	-	Comamonas testosteroni	4-Pregnene-3,20-dione	-	?
additional information	properties of the steroid-enzyme aduct	Comamonas testosteroni	?	-	?

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Release 2023.1 (January 2023)