Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetaminophen | IC50 ketonase reaction 1.0 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.6 microM, pH 6.2, room temperatur | Bos taurus | |
boldine | IC50 ketonase reaction 5.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 77.9 microM, pH 6.2, room temperatur | Bos taurus | |
caffeic acid | IC50 ketonase reaction 0.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.0 microM, pH 6.2, room temperatur | Bos taurus | |
carnosic acid | IC50 ketonase reaction 15.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 115.8 microM, pH 6.2, room temperatur | Bos taurus | |
chlorogenic acid | IC50 ketonase reaction 7.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 127.0 microM, pH 6.2, room temperatur | Bos taurus | |
Cinnamic acid | IC50 ketonase reaction 20.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 229.6 microM, pH 6.2, room temperatur | Bos taurus | |
coumarin | IC50 ketonase reaction 88.8 microM, pH 6.5, room temperatur | Bos taurus | |
curcumin | IC50 ketonase reaction 0.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 12.2 microM, pH 6.2, room temperatur | Bos taurus | |
eugenol | IC50 ketonase reaction 165.9 microM, pH 6.5, room temperatur | Bos taurus | |
ferulic acid | IC50 ketonase reaction 31.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 85.3 microM, pH 6.2, room temperatur | Bos taurus | |
folic acid | IC50 ketonase reaction 62.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 80.2 microM, pH 6.2, room temperatur | Bos taurus | |
galangin | IC50 ketonase reaction 36.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 143.7 microM, pH 6.2, room temperatur | Bos taurus | |
Ibuprofen | IC50 ketonase reaction 10334.3, pH 6.5, room temperatur, IC50 enolase reaction 109.6 microM, pH 6.2, room temperatur | Bos taurus | |
isoeugenol | IC50 ketonase reaction 50.4 microM, pH 6.5, room temperatur, IC50 enolase reaction 129.0 microM, pH 6.2, room temperatur | Bos taurus | |
methotrexate | IC50 ketonase reaction 15.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 63.7 microM, pH 6.2, room temperatur | Bos taurus | |
additional information | 50% inhibition could not be attained: estragol, gentisic acid, tropolone | Bos taurus | |
o-coumaric acid | IC50 ketonase reaction 87.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 175.7 microM, pH 6.2, room temperatur | Bos taurus | |
p-coumaric acid | IC50 ketonase reaction 18.1 microM, pH 6.5, room temperatur, IC50 enolase reaction 103.3 microM, pH 6.2, room temperatur | Bos taurus | |
parthenolide | IC50 ketonase reaction 3624.1 microM, pH 6.5, room temperatur | Bos taurus | |
Phenylbutazone | IC50 ketonase reaction 7126.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 376.6 microM, pH 6.2, room temperatur | Bos taurus | |
phloretin | IC50 ketonase reaction 4.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 84.1 microM, pH 6.2, room temperatur | Bos taurus | |
piroxicam | IC50 ketonase reaction 120.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 74.8 microM, pH 6.2, room temperatur | Bos taurus | |
Quinine | IC50 ketonase reaction 34.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 156.3 microM, pH 6.2, room temperatur | Bos taurus | |
resveratrol | IC50 ketonase reaction 1.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 28.0 microM, pH 6.2, room temperatur | Bos taurus | |
rosmarinic acid | IC50 ketonase reaction 13.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 65.6 microM, pH 6.2, room temperatur | Bos taurus | |
scopoletin | IC50 ketonase reaction 133.8 microM, pH 6.5, room temperatur | Bos taurus | |
umbelliferone | IC50 ketonase reaction 2.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 19.5 microM, pH 6.2, room temperatur | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
keto-phenylpyruvate | - |
Bos taurus | enol-phenylpyruvate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
Macrophage migration inhibitory factor | - |
Bos taurus |
MIF | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | 0.002 | IC50 ketonase reaction 0.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.0 microM, pH 6.2, room temperatur | Bos taurus | caffeic acid | |
0.0007 | - |
IC50 ketonase reaction 0.7 microM, pH 6.5, room temperatur | Bos taurus | curcumin | |
0.001 | - |
IC50 ketonase reaction 1.0 microM, pH 6.5, room temperatur | Bos taurus | acetaminophen | |
0.0019 | - |
IC50 ketonase reaction 1.9 microM, pH 6.5, room temperatur | Bos taurus | resveratrol | |
0.0026 | - |
IC50 enolase reaction 2.6 microM, pH 6.2, room temperatur | Bos taurus | acetaminophen | |
0.0026 | 0.0195 | IC50 ketonase reaction 2.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 19.5 microM, pH 6.2, room temperatur | Bos taurus | umbelliferone | |
0.0048 | - |
IC50 ketonase reaction 4.8 microM, pH 6.5, room temperatur | Bos taurus | phloretin | |
0.0057 | - |
IC50 ketonase reaction 5.7 microM, pH 6.5, room temperatur | Bos taurus | boldine | |
0.0076 | - |
IC50 ketonase reaction 7.6 microM, pH 6.5, room temperatur | Bos taurus | chlorogenic acid | |
0.0122 | - |
IC50 enolase reaction 12.2 microM, pH 6.2, room temperatur | Bos taurus | curcumin | |
0.0138 | - |
IC50 ketonase reaction 13.8 microM, pH 6.5, room temperatur | Bos taurus | rosmarinic acid | |
0.0155 | - |
IC50 ketonase reaction 15.5 microM, pH 6.5, room temperatur | Bos taurus | carnosic acid | |
0.0156 | - |
IC50 ketonase reaction 15.6 microM, pH 6.5, room temperatur | Bos taurus | methotrexate | |
0.0181 | 0.1033 | IC50 ketonase reaction 18.1 microM, pH 6.5, room temperatur, IC50 enolase reaction 103.3 microM, pH 6.2, room temperatur | Bos taurus | p-coumaric acid | |
0.0209 | 0.2296 | IC50 ketonase reaction 20.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 229.6 microM, pH 6.2, room temperatur | Bos taurus | Cinnamic acid | |
0.028 | - |
IC50 enolase reaction 28.0 microM, pH 6.2, room temperatur | Bos taurus | resveratrol | |
0.0317 | - |
IC50 ketonase reaction 31.7 microM, pH 6.5, room temperatur | Bos taurus | ferulic acid | |
0.0349 | - |
IC50 ketonase reaction 34.9 microM, pH 6.5, room temperatur | Bos taurus | Quinine | |
0.0369 | - |
IC50 ketonase reaction 36.9 microM, pH 6.5, room temperatur | Bos taurus | galangin | |
0.0504 | - |
IC50 ketonase reaction 50.4 microM, pH 6.5, room temperatur | Bos taurus | isoeugenol | |
0.0627 | - |
IC50 ketonase reaction 62.7 microM, pH 6.5, room temperatur | Bos taurus | folic acid | |
0.0637 | - |
IC50 enolase reaction 63.7 microM, pH 6.2, room temperatur | Bos taurus | methotrexate | |
0.0656 | - |
IC50 enolase reaction 65.6 microM, pH 6.2, room temperatur | Bos taurus | rosmarinic acid | |
0.0748 | - |
IC50 enolase reaction 74.8 microM, pH 6.2, room temperatur | Bos taurus | piroxicam | |
0.0779 | - |
IC50 enolase reaction 77.9 microM, pH 6.2, room temperatur | Bos taurus | boldine | |
0.0802 | - |
IC50 enolase reaction 80.2 microM, pH 6.2, room temperatur | Bos taurus | folic acid | |
0.0802 | - |
80.2 microM | Bos taurus | folic acid | |
0.0841 | - |
IC50 enolase reaction 84.1 microM, pH 6.2, room temperatur | Bos taurus | phloretin | |
0.0853 | - |
IC50 enolase reaction 85.3 microM, pH 6.2, room temperatur | Bos taurus | ferulic acid | |
0.0878 | - |
IC50 ketonase reaction 87.8 microM, pH 6.5, room temperatur | Bos taurus | o-coumaric acid | |
0.0888 | - |
IC50 ketonase reaction 88.8 microM, pH 6.5, room temperatur | Bos taurus | coumarin | |
0.1096 | - |
IC50 enolase reaction 109.6 microM, pH 6.2, room temperatur | Bos taurus | Ibuprofen | |
0.1158 | - |
IC50 enolase reaction 115.8 microM, pH 6.2, room temperatur | Bos taurus | carnosic acid | |
0.1209 | - |
IC50 ketonase reaction 120.9 microM, pH 6.5, room temperatur | Bos taurus | piroxicam | |
0.127 | - |
IC50 enolase reaction 127.0 microM, pH 6.2, room temperatur | Bos taurus | chlorogenic acid | |
0.129 | - |
IC50 enolase reaction 129.0 microM, pH 6.2, room temperatur | Bos taurus | isoeugenol | |
0.1338 | - |
IC50 ketonase reaction 133.8 microM, pH 6.5, room temperatur | Bos taurus | scopoletin | |
0.1437 | - |
IC50 enolase reaction 143.7 microM, pH 6.2, room temperatur | Bos taurus | galangin | |
0.1563 | - |
IC50 enolase reaction 156.3 microM, pH 6.2, room temperatur | Bos taurus | Quinine | |
0.1659 | - |
IC50 ketonase reaction 165.9 microM, pH 6.5, room temperatur | Bos taurus | eugenol | |
0.1757 | - |
IC50 enolase reaction 175.7 microM, pH 6.2, room temperatur | Bos taurus | o-coumaric acid | |
0.3766 | - |
IC50 enolase reaction 376.6 microM, pH 6.2, room temperatur | Bos taurus | Phenylbutazone | |
3.6241 | - |
IC50 ketonase reaction 3624.1 microM, pH 6.5, room temperatur | Bos taurus | parthenolide | |
7.1267 | - |
IC50 ketonase reaction 7126.7 microM, pH 6.5, room temperatur | Bos taurus | Phenylbutazone | |
10.3343 | - |
IC50 ketonase reaction 10334.3 microM, pH 6.5, room temperatur | Bos taurus | Ibuprofen |