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Literature summary for 5.3.2.1 extracted from
- Thyroidal phenylpyruvate tautomerase (1969), J. Biol. Chem., 244, 4864-4870.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.2 | - |
(4-hydroxyphenyl)pyruvate | thyroid gland | Sus scrofa |  |
| 8 | - |
phenylpyruvate | thyroid gland | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | 44000 | gel filtration, sucrose density gradient centrifugation | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Sus scrofa | role in the biosynthesis of thyroxine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| kidney | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thyroid gland | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.3 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 6 weeks, no loss of activity | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-(4-hydroxyphenyl)pyruvate | keto-form | Sus scrofa | 2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoate | - |
? | |
| additional information | role in the biosynthesis of thyroxine | Sus scrofa | ? | - |
? | |
| Phenylpyruvate | - |
Sus scrofa | Phenylpyruvate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
30 min, no loss of activity, 90 min, more the 70% loss of activity | Sus scrofa |
| 72 | - |
5 min, no loss of activity | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
- |
Sus scrofa |
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Release 2023.1 (January 2023)
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