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Literature summary for 5.3.1.9 extracted from
- Aldose-ketose isomerases (1972), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 6, 271-354.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | use as a diagnostic tool in medicine | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,5-Anhydroglucitol 6-phosphate | - |
Saccharomyces cerevisiae |  |
| 2-deoxyglucose 6-phosphate | - |
Saccharomyces cerevisiae | |
| 6-phosphogluconate | - |
Entamoeba sp. | |
| 6-phosphogluconate | - |
Escherichia coli | |
| 6-phosphogluconate | - |
Homo sapiens | |
| 6-phosphogluconate | - |
Oryctolagus cuniculus | |
| 6-phosphogluconate | - |
Pisum sativum | |
| 6-phosphogluconate | - |
Saccharomyces cerevisiae | |
| Erythritol 4-phosphate | - |
Saccharomyces cerevisiae | |
| erythrose 4-phosphate | - |
Saccharomyces cerevisiae | |
| fructose 1,6-diphosphate | - |
Oryctolagus cuniculus | |
| fructose 1-phosphate | - |
Oryctolagus cuniculus | |
| L-Sorbose 6-phosphate | - |
Saccharomyces cerevisiae | |
| L-xylulose 5-phosphate | - |
Saccharomyces cerevisiae | |
| mannitol 6-phosphate | - |
Saccharomyces cerevisiae | |
| mannose 6-phosphate | - |
Saccharomyces cerevisiae | |
| ribose 5-phosphate | - |
Saccharomyces cerevisiae | |
| ribulose 5-phosphate | - |
Saccharomyces cerevisiae | |
| sedoheptulose 7-phosphate | - |
Saccharomyces cerevisiae | |
| sorbitol 6-phosphate | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | 0.17 | fructose 6-phosphate | muscle enzyme, values of 0.01 mM, 0.12 mM and 0.17 mM are determined by different authors | Oryctolagus cuniculus | |
| 0.03 | 0.8 | glucose 6-phosphate | muscle enzyme, values of 0.03 mM, 0.31 mM and 0.8 mM are determined by different authors | Oryctolagus cuniculus | |
| 0.07 | - |
fructose 6-phosphate | mammary gland enzyme | Bos taurus | |
| 0.1 | - |
fructose 6-phosphate | - |
Bos taurus | |
| 0.1 | - |
fructose 6-phosphate | - |
Oryctolagus cuniculus | |
| 0.1 | - |
fructose 6-phosphate | - |
Schistosoma mansoni | |
| 0.11 | 0.23 | fructose 6-phosphate | values of 0.11 mM, 0.15 mM and 0.23 mM are determined by different autors | Saccharomyces cerevisiae | |
| 0.12 | - |
fructose 6-phosphate | - |
Homo sapiens | |
| 0.12 | - |
fructose 6-phosphate | liver enzyme | Oryctolagus cuniculus | |
| 0.12 | 0.57 | glucose 6-phosphate | mammary gland enzyme, values of 0.12 mM and 0.57 mM are determined by different authors | Bos taurus | |
| 0.21 | - |
fructose 6-phosphate | erythrocyte enzyme, wild-type | Oryctolagus cuniculus | |
| 0.27 | - |
glucose 6-phosphate | - |
Pisum sativum | |
| 0.3 | 1.5 | glucose 6-phosphate | values of 0.27 mM, 0.3 mM, 0.7 mM, 0.8 mM and 1.5 mM are determined by different authors | Saccharomyces cerevisiae | |
| 0.36 | - |
glucose 6-phosphate | - |
Klebsiella aerogenes | |
| 0.6 | - |
glucose 6-phosphate | liver enzyme | Oryctolagus cuniculus | |
| 0.74 | - |
fructose 6-phosphate | erythrocyte enzyme, mutant B9 | Oryctolagus cuniculus | |
| 2 | - |
glucose 6-phosphate | - |
Apis mellifera | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
mammary gland, low speed sedimentation without reaching equilibrium | Bos taurus |
| 110000 | 120000 | - |
Pisum sativum |
| 130000 | 140000 | - |
Oryctolagus cuniculus |
| 145000 | - |
calculation from sedimentation coefficient and diffusion coefficient | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | - |
Spanish, Indian and American honeybee | - |
| Aspergillus niger | - |
- |
- |
| Bos taurus | - |
- |
- |
| Canis lupus familiaris | - |
- |
- |
| Entamoeba sp. | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Pisum sativum | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
multiple forms | - |
| Schistosoma mansoni | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Trypanosoma sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Bos taurus |
- |
Aspergillus niger |
- |
Klebsiella aerogenes |
- |
Mycobacterium tuberculosis |
- |
Apis mellifera |
- |
Schistosoma mansoni |
- |
Trypanosoma sp. |
- |
Entamoeba sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| intestinal mucosa | - |
Bos taurus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Canis lupus familiaris | - |
| mammary gland | - |
Bos taurus | - |
| milk | - |
Bos taurus | - |
| muscle | - |
Sus scrofa | - |
| muscle | skeletal | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fructose 6-phosphate | - |
Escherichia coli | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | - |
Schistosoma mansoni | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | - |
Entamoeba sp. | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | r | Homo sapiens | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | r | Saccharomyces cerevisiae | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | r | Bos taurus | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | r | Oryctolagus cuniculus | Glucose 6-phosphate | - |
? | |
| Fructose 6-phosphate | - |
Escherichia coli B / ATCC 11303 | Glucose 6-phosphate | - |
? | |
| Glucose 6-phosphate | - |
Pisum sativum | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | - |
Klebsiella aerogenes | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | - |
Apis mellifera | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | r | Homo sapiens | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | r | Saccharomyces cerevisiae | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | r | Bos taurus | Fructose 6-phosphate | - |
? | |
| Glucose 6-phosphate | r | Oryctolagus cuniculus | Fructose 6-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Escherichia coli |
| dimer | - |
Homo sapiens |
| dimer | - |
Sus scrofa |
| dimer | - |
Saccharomyces cerevisiae |
| dimer | - |
Bos taurus |
| dimer | - |
Pisum sativum |
| dimer | 2 * 60000-70000, SDS-PAGE, SDS velocity centrifugation, maleic anhydride velocity and equilibrium sedimentation, urea velocity sedimentation, propionic acid velocity sedimentation guanidine-HCl velocity and equilibrium sedimentation | Oryctolagus cuniculus |
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