Literature summary for 5.3.1.8 extracted from

Ahmad, L.; Plancqueel, S.; Dubosclard, V.; Lazar, N.; Ghattas, W.; Li de la Sierra-Gallay, I.; van Tilbeurgh, H.; Salmon, L.
Crystal structure of phosphomannose isomerase from Candida albicans complexed with 5-phospho-D-arabinonhydrazide (2018), FEBS Lett., 592, 1667-1680 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure complexed with inhibitor 5-phospho-D-arabinonhydrazide at 1.85 A resolution. Glu294 is the catalytic base that transfers a proton between the C1 and C2 carbon atoms of the substrate. The inhibitor shows bidentate coordination	Candida albicans

Inhibitors

Inhibitors	Comment	Organism	Structure
5-phospho-D-arabinonhydrazide	-	Candida albicans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.13	-	D-mannose 6-phosphate	pH not specified in the publication, temperature not specified in the publication	Candida albicans

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	The Zn binding mode of the 5-phospho-D-arabinonhydrazide inhibitor mimics the bidentate Zn coordination of substrate and high energy intermediate	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	P34948	-	-
Candida albicans ATCC MYA-2876	P34948	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Mannose 6-phosphate	-	Candida albicans	D-Fructose 6-phosphate	-	r
D-Mannose 6-phosphate	-	Candida albicans ATCC MYA-2876	D-Fructose 6-phosphate	-	r

Synonyms

Synonyms	Comment	Organism
Pmi1	-	Candida albicans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0017	-	5-phospho-D-arabinonhydrazide	pH not specified in the publication, temperature not specified in the publication	Candida albicans

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Release 2023.1 (January 2023)