Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.8 extracted from

  • Cleasby, A.; Wonacott, A.; Skarzynski, T.; Hubbard, R.E.; Davies, G.J.; Proudfoot, A.E.I.; Bernard, A.R.; Payton, M.A.; Wells, T.N.C.
    The X-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 A resolution (1996), Nat. Struct. Biol., 3, 470-479.
    View publication on PubMed
Search for more literature for 5.3.1.8

Application

Application Comment Organism
pharmacology absence of mannose-6-phosphate isomerase causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs Candida albicans

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Candida albicans

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc enzyme contains an essential zinc atom. Four of the five ligands come from the protein, one of these ligands is unique in that it is a glutamine Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Candida albicans reversible isomerization of mannose 6-phosphate and fructose 6-phosphate is the initial commited step in the synthesis of the mannosylated glycoproteins, which are essential in biosynthesis of functional fungal cell wall. Absence of mannose-6-phosphate isomerase causes cell lysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 6-phosphate
-
 Candida albicans D-Fructose 6-phosphate
-
 ?
additional information reversible isomerization of mannose 6-phosphate and fructose 6-phosphate is the initial commited step in the synthesis of the mannosylated glycoproteins, which are essential in biosynthesis of functional fungal cell wall. Absence of mannose-6-phosphate isomerase causes cell lysis Candida albicans ?
-
 ?