Protein Variants | Comment | Organism |
---|---|---|
C150A | mutant Cys150Ala shows similar Km-values and maximal velocity as compared to the wild-type enzyme. The mutant enzyme shows no inhibition by silver sulfadiazine, and is 1000fold less sensitive to Hg2+ inhibition | Candida albicans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ag+ | irreversible inhibition in a two-step process, mannose 6-phosphate protects against inactivation. Mutant enzyme Cys150Ala shows 1000fold less sensitivity than the wild-type enzyme | Candida albicans | |
Silver sulfadiazine | wild-type enzyme is inhibited, mutant enzyme Cys150Ala is not inhibited | Candida albicans | |
Silver sulfadiazine | no inhibition | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Candida albicans | enzyme is involved in biosynthesis of mannan components of the cell walls | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Mannose 6-phosphate | - |
Escherichia coli | D-Fructose 6-phosphate | - |
? | |
D-Mannose 6-phosphate | - |
Candida albicans | D-Fructose 6-phosphate | - |
? | |
additional information | enzyme is involved in biosynthesis of mannan components of the cell walls | Candida albicans | ? | - |
? |