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Literature summary for 5.3.1.8 extracted from
- Aldose-ketose isomerases (1972), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 6, 271-354.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-phosphogluconate | competitive | Saccharomyces cerevisiae |  |
| erythrose 4-phosphate | - |
Homo sapiens | |
| erythrose 4-phosphate | competitive | Saccharomyces cerevisiae | |
| erythrose 4-phosphate | - |
Sus scrofa | |
| galactose 6-phosphate | competitive | Saccharomyces cerevisiae | |
| glucosamine 6-phosphate | competitive | Saccharomyces cerevisiae | |
| glucose 1-phosphate | competitive | Saccharomyces cerevisiae | |
| glucose 6-phosphate | competitive | Saccharomyces cerevisiae | |
| mannitol 1-phosphate | competitive | Saccharomyces cerevisiae | |
| phosphate | competitive | Saccharomyces cerevisiae | |
| ribose 5-phosphate | competitive | Saccharomyces cerevisiae | |
| sorbitol 6-phosphate | competitive | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.35 | - |
mannose 6-phosphate | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Fructose 6-phosphate | Homo sapiens | - |
? | - |
? | |
| D-Fructose 6-phosphate | Microorganisms | mannose 6-phosphate produced in this manner can be incorporated via mannose 1-phosphate as intermediate into guanosine diphosphomannose which participates in numerous processes related to cell wall biosynthesis | ? | - |
? | |
| D-Mannose 6-phosphate | Mammalia | channeling D-mannose 6-phosphate into glycolysis by isomerization to fructose 6-phosphate | ? | - |
? | |
| additional information | Homo sapiens | - |
? | - |
? | |
| additional information | Klebsiella aerogenes | constitutive enzyme | ? | - |
? | |
| additional information | Pseudomonas aeruginosa | adaptive enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | - |
- |
- |
| Ascaris suum | - |
- |
- |
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Mammalia | - |
- |
- |
| Microorganisms | - |
- |
- |
| Nakazawaea holstii | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Ovis aries | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| artery | - |
Homo sapiens | - |
| erythrocyte | - |
Sus scrofa | - |
| erythrocyte | - |
Homo sapiens | - |
| intestinal mucosa | - |
Bos taurus | - |
| muscle | - |
Oryctolagus cuniculus | - |
| muscle | skeletal | Sus scrofa | - |
| muscle | skeletal | Rattus norvegicus | - |
| muscle | skeletal | Cavia porcellus | - |
| muscle | skeletal | Ovis aries | - |
| muscle | skeletal | Bos taurus | - |
| muscle | skeletal | Homo sapiens | - |
| testis | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Fructose 6-phosphate | - |
Homo sapiens | ? | - |
? | |
| D-Fructose 6-phosphate | mannose 6-phosphate produced in this manner can be incorporated via mannose 1-phosphate as intermediate into guanosine diphosphomannose which participates in numerous processes related to cell wall biosynthesis | Microorganisms | ? | - |
? | |
| D-Mannose 6-phosphate | - |
Cavia porcellus | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Mammalia | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Homo sapiens | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Rattus norvegicus | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Sus scrofa | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Saccharomyces cerevisiae | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Bos taurus | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Oryctolagus cuniculus | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Ovis aries | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Klebsiella aerogenes | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Pseudomonas aeruginosa | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Ascaris suum | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Apis mellifera | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Nakazawaea holstii | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Microorganisms | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | channeling D-mannose 6-phosphate into glycolysis by isomerization to fructose 6-phosphate | Mammalia | ? | - |
? | |
| additional information | - |
Homo sapiens | ? | - |
? | |
| additional information | constitutive enzyme | Klebsiella aerogenes | ? | - |
? | |
| additional information | adaptive enzyme | Pseudomonas aeruginosa | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.2 | - |
Saccharomyces cerevisiae |
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