Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-phospho-D-ribonamide | - |
Escherichia coli | |
5-phospho-D-ribonamide | - |
Mycobacterium tuberculosis | |
5-phospho-D-ribonate | competitive inhibitor of a Rpi, displays specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview | Escherichia coli | |
5-phospho-D-ribonate | very strong competitive inhibitor of a Rpi, specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview | Mycobacterium tuberculosis | |
5-phospho-D-ribonohydroxamic acid | - |
Escherichia coli | |
5-phospho-D-ribonohydroxamic acid | - |
Mycobacterium tuberculosis | |
additional information | substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview | Escherichia coli | |
additional information | substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview | Mycobacterium tuberculosis | |
N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate | - |
Escherichia coli | |
N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate | - |
Mycobacterium tuberculosis | |
N-(5-phospho-D-ribonoyl)-glycine | poor inhibition with substrate D-ribose 5-phosphate, no inhibition with substrate D-allose 5-phosphate | Escherichia coli | |
N-(5-phospho-D-ribonoyl)-glycine | - |
Mycobacterium tuberculosis | |
N-(5-phospho-D-ribonoyl)-hydrazine | - |
Escherichia coli | |
N-(5-phospho-D-ribonoyl)-hydrazine | - |
Mycobacterium tuberculosis | |
N-(5-phospho-D-ribonoyl)-methylamine | - |
Escherichia coli | |
N-(5-phospho-D-ribonoyl)-methylamine | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-ribose 5-phosphate | Escherichia coli | - |
D-ribulose 5-phosphate | - |
r | |
D-ribose 5-phosphate | Mycobacterium tuberculosis | - |
D-ribulose 5-phosphate | - |
r | |
D-ribose 5-phosphate | Mycobacterium tuberculosis H37Rv | - |
D-ribulose 5-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene rpiB | - |
Mycobacterium tuberculosis | P9WKD7 | gene rpiB | - |
Mycobacterium tuberculosis H37Rv | P9WKD7 | gene rpiB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-allose 6-phosphate | - |
Escherichia coli | D-allulose 6-phosphate | - |
r | |
D-allose 6-phosphate | - |
Mycobacterium tuberculosis | D-allulose 6-phosphate | - |
r | |
D-allose 6-phosphate | - |
Mycobacterium tuberculosis H37Rv | D-allulose 6-phosphate | - |
r | |
D-ribose 5-phosphate | - |
Escherichia coli | D-ribulose 5-phosphate | - |
r | |
D-ribose 5-phosphate | - |
Mycobacterium tuberculosis | D-ribulose 5-phosphate | - |
r | |
D-ribose 5-phosphate | - |
Mycobacterium tuberculosis H37Rv | D-ribulose 5-phosphate | - |
r | |
additional information | enzyme substrate synthesis, overview | Escherichia coli | ? | - |
? | |
additional information | enzyme substrate synthesis, overview | Mycobacterium tuberculosis | ? | - |
? | |
additional information | enzyme substrate synthesis, overview | Mycobacterium tuberculosis H37Rv | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-Ribose 5-phosphate isomerase | - |
Escherichia coli |
D-Ribose 5-phosphate isomerase | - |
Mycobacterium tuberculosis |
EcRpiB | - |
Escherichia coli |
MtRpiB | - |
Mycobacterium tuberculosis |
RpiB | - |
Escherichia coli |
RpiB | - |
Mycobacterium tuberculosis |
type B ribose 5-phosphate isomerase | - |
Escherichia coli |
type B ribose 5-phosphate isomerase | - |
Mycobacterium tuberculosis |
type B Rpi | - |
Escherichia coli |
type B Rpi | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Escherichia coli |
7.5 | - |
assay at | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
5-phospho-D-ribonate | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | |
0.04 | - |
5-phospho-D-ribonamide | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | |
0.07 | - |
5-phospho-D-ribonamide | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | |
0.09 | - |
5-phospho-D-ribonohydroxamic acid | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | |
0.11 | - |
N-(5-phospho-D-ribonoyl)-methylamine | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | |
0.18 | - |
N-(5-phospho-D-ribonoyl)-methylamine | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | |
0.26 | - |
5-phospho-D-ribonohydroxamic acid | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | |
0.34 | - |
N-(5-phospho-D-ribonoyl)-glycine | pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | |
0.43 | - |
5-phospho-D-ribonohydroxamic acid | pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli | |
1.9 | - |
N-(5-phospho-D-ribonoyl)-hydrazine | pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.031 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | 5-phospho-D-ribonate | |
0.17 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | 5-phospho-D-ribonohydroxamic acid | |
0.19 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | N-(5-phospho-D-ribonoyl)-methylamine | |
0.2 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | 5-phospho-D-ribonamide | |
0.22 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | 5-phospho-D-ribonamide | |
0.35 | - |
pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli | N-(5-phospho-D-ribonoyl)-methylamine | |
0.36 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | N-(5-phospho-D-ribonoyl)-methylamine | |
0.44 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | 5-phospho-D-ribonohydroxamic acid | |
0.57 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | N-(5-phospho-D-ribonoyl)-glycine | |
0.62 | - |
pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli | 5-phospho-D-ribonohydroxamic acid | |
1 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | N-(5-phospho-D-ribonoyl)-hydrazine | |
1.31 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | 5-phospho-D-ribonate | |
1.33 | - |
pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli | 5-phospho-D-ribonamide | |
1.42 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Mycobacterium tuberculosis | N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate | |
1.6 | - |
pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate | Escherichia coli | N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate | |
2 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate | |
9 | - |
pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate | Escherichia coli | N-(5-phospho-D-ribonoyl)-glycine |
General Information | Comment | Organism |
---|---|---|
metabolism | ribose 5-phosphate isomerase is a key enzyme of the pentose phosphate pathway | Escherichia coli |
metabolism | ribose 5-phosphate isomerase is a key enzyme of the pentose phosphate pathway | Mycobacterium tuberculosis |