Literature summary for 5.3.1.28 extracted from

Durka, M.; Tikad, A.; Perion, R.; Bosco, M.; Andaloussi, M.; Floquet, S.; Malacain, E.; Moreau, F.; Oxoby, M.; Gerusz, V.; Vincent, S.P.
Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis (2011), Chemistry, 17, 11305-11313.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-[(1R)-1-hydroxy-2-(phosphonoamino)ethyl]-D-lyxopyranose	-	Escherichia coli
5-[(1R)-2-[4,5-bis(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-hydroxyethyl]-D-lyxopyranose	poor inhibitor	Escherichia coli
5-[(1R,2R)-2-carboxy-1,2-dihydroxyethyl]-D-lyxopyranose	-	Escherichia coli
5-[(1S,2S)-1,2-dihydroxy-2-phosphonoethyl]-D-lyxopyranose	-	Escherichia coli
5-{(1R)-1-hydroxy-2-[(methylsulfonyl)amino]ethyl}-D-lyxopyranose	poor inhibitor	Escherichia coli
methyl 5-[(1R)-1-hydroxy-2-(phosphonooxy)ethyl]-alpha-D-lyxopyranoside	-	Escherichia coli
methyl 5-[(1R)-1-hydroxy-2-(phosphonooxy)ethyl]-alpha-D-xylopyranoside	-	Escherichia coli
methyl 5-[(1R,2R)-2-carboxy-1,2-dihydroxyethyl]-alpha-D-lyxopyranoside	poor inhibitor	Escherichia coli
methyl 5-[(1S)-1-hydroxy-2-(phosphonooxy)ethyl]-alpha-D-lyxopyranoside	poor inhibitor	Escherichia coli
methyl 5-[(1S,2S)-1,2-dihydroxy-2-phosphonoethyl]-alpha-D-lyxopyranoside	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-sedoheptulose 7-phosphate	Escherichia coli	-	D-glycero-D-manno-heptose 7-phosphate	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-sedoheptulose 7-phosphate	-	Escherichia coli	D-glycero-D-manno-heptose 7-phosphate	-	r

Synonyms

Synonyms	Comment	Organism
GmhA	-	Escherichia coli

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Release 2023.1 (January 2023)