Literature summary for 5.3.1.24 extracted from

Braus, G.H.; Luger, K.; Paravicini, G.; Schmidheini, T.; Kirschner, K.; Huetter, R.
The role of the TRP1 gene in tryptophan biosynthesis (1988), J. Biol. Chem., 263, 7868-7875.

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Cloned(Commentary)

Cloned (Comment)	Organism
separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase	Saccharomyces cerevisiae
TRP1 gene regulation, cloning	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.004	0.005	N-(5-phospho-beta-D-ribosyl)anthranilate	30°C	Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
23000	-	gel filtration	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate	Saccharomyces cerevisiae	third step in tryptophan biosynthesis	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?
N-(5-phospho-beta-D-ribosyl)anthranilate	Saccharomyces cerevisiae	involved in tryptophan biosynthesis from chorismate	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase	-
Saccharomyces cerevisiae	-	transformant strain RH218 (YARp1)	-

Purification (Commentary)

Purification (Comment)	Organism
165fold	Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Saccharomyces cerevisiae
102	-	-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate	-	Saccharomyces cerevisiae	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	ir
N-(5-phospho-beta-D-ribosyl)anthranilate	third step in tryptophan biosynthesis	Saccharomyces cerevisiae	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?
N-(5-phospho-beta-D-ribosyl)anthranilate	involved in tryptophan biosynthesis from chorismate	Saccharomyces cerevisiae	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?

Subunits

Subunits	Comment	Organism
monomer	-	Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
50	60	N-(5-phospho-beta-D-ribosyl)anthranilate	30°C	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)