Protein Variants | Comment | Organism |
---|---|---|
additional information | in isoform Pin1-deficient neuronal cell cultures, H2O2 stress-induced phosphoprotein Tau dephosphorylation at Thr231 is significantly lower than in wild-type neurons | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
juglone | pharmacological inhibitor of isoform Pin1, application of juglone partially prevents dephosphorylation of phosphoptotein Tau at Thr231 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | B0BNL2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | primary cortical neuron, enzyme isoform Pin1 partly colocalizes with phosphoprotein Tau,which is involved in Alzheimers disease | Rattus norvegicus | - |