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Literature summary for 5.2.1.8 extracted from

  • Picken, N.C.; Eschenlauer, S.; Taylor, P.; Page, A.P.; Walkinshaw, M.D.
    Structural and biological characterisation of the gut-associated cyclophilin B isoforms from Caenorhabditis elegans (2002), J. Mol. Biol., 322, 15-25.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapour-diffusion method, CYP-5, X-ray structure solved to a resolution of 1.75 A Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A IC50: 50 nM Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Caenorhabditis elegans 5737
-

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans P52014 the organism expressed 18 cyclophilin isoforms, eight of which are conserved single domain forms, comprising two closely related secreted or type B forms, CYP-5 and CYP-6
-

Purification (Commentary)

Purification (Comment) Organism
CYP-5 Caenorhabditis elegans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
-
Caenorhabditis elegans N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
-
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Synonyms

Synonyms Comment Organism
CYP-5
-
Caenorhabditis elegans
CYP-6
-
Caenorhabditis elegans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
IC50: 50 nM Caenorhabditis elegans cyclosporin A