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Literature summary for 5.1.99.6 extracted from
- Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals (2014), Biochem. J., 460, 49-58.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Aibp, expression of GFP-fused or Myc-tagged mAIBP in CHO cells and in HEK-293 cells, in vitro transcription-translation assays, full-length coding sequences of the mouse mAIBP | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| mitochondrion | mainly | Mus musculus | 5739 | - |
| mitochondrion | mainly | Rattus norvegicus | 5739 | - |
| mitochondrion | mainly | Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | Mus musculus | i.e. NADHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r |  |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | Rattus norvegicus | i.e. NADHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | Homo sapiens | i.e. NADHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | Mus musculus | i.e. NADPHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | Rattus norvegicus | i.e. NADPHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | Homo sapiens | i.e. NADPHX | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8NCW5 | gene Aibp | - |
| Mus musculus | Q8K4Z3 | gene Aibp | - |
| Rattus norvegicus | B0BNM1 | gene Aibp | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native AIBP protein from liver by anion exchange chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | i.e. NADHX | Mus musculus | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | i.e. NADHX | Rattus norvegicus | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | i.e. NADHX | Homo sapiens | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | i.e. NADPHX | Mus musculus | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | i.e. NADPHX | Rattus norvegicus | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
| (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | i.e. NADPHX | Homo sapiens | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AIBP | - |
Mus musculus |
| AIBP | - |
Rattus norvegicus |
| AIBP | - |
Homo sapiens |
| NAD(P)HX epimerase | - |
Mus musculus |
| NAD(P)HX epimerase | - |
Rattus norvegicus |
| NAD(P)HX epimerase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | - |
assay at | Mus musculus |
| 7.1 | - |
assay at | Rattus norvegicus |
| 7.1 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively | Mus musculus |
| physiological function | hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively | Rattus norvegicus |
| physiological function | hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively | Homo sapiens |
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