Application | Comment | Organism |
---|---|---|
medicine | AMACR is expressed in prostate cancer cell lines but is absent in normal and non-tumour prostate epithelial cell lines. Presence of trifluoroibuprofen induces down-modulation of AMACR expression, suppression of the survival Akt/mTOR signalling pathway and down-modulation of cyclin D1 and survivin with G2/M arrest and apoptosis. Oral administration is associated with acute toxicity at doses >75 mg/Kg/day | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UHK6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
AMACR | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | presence of trifluoroibuprofen induces down-modulation of AMACR expression, suppression of the survival Akt/mTOR signalling pathway and down-modulation of cyclin D1 and survivin with G2/M arrest and apoptosis | down |