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Literature summary for 5.1.99.4 extracted from

  • Festuccia, C.; Gravina, G.L.; Mancini, A.; Muzi, P.; Cesare, E.D.; Kirk, R.; Smith, M.; Hughes, S.; Gibson, R.; Lian, L.Y.; Ricevuto, E.; Carnell, A.J.
    Trifluoroibuprofen inhibits alpha-methylacyl coenzyme A racemase (AMACR/P504S), reduces cancer cell proliferation and inhibits in vivo tumor growth in aggressive prostate cancer models (2014), Anticancer Agents Med. Chem., 14, 1031-1041 .
    View publication on PubMed

Application

Application Comment Organism
medicine AMACR is expressed in prostate cancer cell lines but is absent in normal and non-tumour prostate epithelial cell lines. Presence of trifluoroibuprofen induces down-modulation of AMACR expression, suppression of the survival Akt/mTOR signalling pathway and down-modulation of cyclin D1 and survivin with G2/M arrest and apoptosis. Oral administration is associated with acute toxicity at doses >75 mg/Kg/day Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UHK6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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Homo sapiens
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Synonyms

Synonyms Comment Organism
AMACR
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens presence of trifluoroibuprofen induces down-modulation of AMACR expression, suppression of the survival Akt/mTOR signalling pathway and down-modulation of cyclin D1 and survivin with G2/M arrest and apoptosis down