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Literature summary for 5.1.3.8 extracted from

  • Takahashi, S.; Hori, K.; Ogasawara, H.; Hiwatashi, K.; Sugiyama, T.
    Effects of nucleotides on the interaction of renin with GlcNAc 2-epimerase (renin binding protein, RnBP) (2006), J. Biochem., 140, 725-730.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP stabilizes the dimeric form of the enzyme Sus scrofa
ATP stabilizes the dimeric form of the enzyme, inhibits the heterocomplex with renin, prevents inhibition by NEM, inhibits degradation of the enzyme by thermolysin Sus scrofa
dATP stabilizes the dimeric form of the enzyme Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide NEM, strong inhibitor in absence of ATP at 0.1-0.3 mM, at 5mM inhibition also in presence of ATP Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
monomer, gel filtration Sus scrofa
65000
-
dimer, gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P17560
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-mannosamine
-
Sus scrofa N-acetyl-D-glucosamine
-
?

Subunits

Subunits Comment Organism
dimer resistant to protease digestion Sus scrofa

Synonyms

Synonyms Comment Organism
GlcNAc 2-epimerase
-
Sus scrofa
N-acyl-D-glucosamine 2-epimerase
-
Sus scrofa
N-acylglucosamine 2-epimerase
-
Sus scrofa
renin binding protein
-
Sus scrofa
RNBP inhibits activity of renin, forms heterocomplex with renin, high molecular weight renin, HMW Sus scrofa