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Literature summary for 5.1.3.7 extracted from

  • Demendi, M.; Ishiyama, N.; Lam, J.S.; Berghuis, A.M.; Creuzenet, C.
    Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP (2005), Biochem. J., 389, 173-180.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
A209H mutant enzyme shows very limited epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine and slightly reduced epimerization activity with UDP-D-glucose and UDP-D-galactose Pseudomonas aeruginosa
A209N mutant enzyme shows slightly reduced epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine and very limited epimerization activity with UDP-D-glucose and UDP-D-galactose Pseudomonas aeruginosa
G102K mutant enzyme shows slightly reduced epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine and no epimerization activity with UDP-D-glucose and UDP-D-galactose Pseudomonas aeruginosa
Q201E mutant enzyme shows slightly epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine similar to wild-type activity and very limited epimerization activity with UDP-D-Glc and UDP-D-Gal Pseudomonas aeruginosa
Q201E/G102K mutant enzyme shows slightly reduced epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine, no epimerization activity with UDP-D-glucose and very limited activity with UDP-D-galactose Pseudomonas aeruginosa
S143A mutant enzyme shows epimerization activity with UDP-N-acetyl-D-glucosamine and UDP-N-acetyl-D-galactosamine similar to wild-type enzyme and no epimerization activity with UDP-D-glucose and UDP-D-galactose Pseudomonas aeruginosa
S144K mutant enzyme shows no epimerization activity with UDP-N-acetyl-D-glucosamine/UDP-N-acetyl-D-galactosamine and UDP-D-glucose/UDP-D-galactose Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-D-glucose
-
 Pseudomonas aeruginosa UDP-D-galactose
-
 r
UDP-N-acetyl-D-glucosamine
-
 Pseudomonas aeruginosa UDP-N-acetyl-D-galactosamine
-
 r

Synonyms

Synonyms Comment Organism
WbPP
-
 Pseudomonas aeruginosa